A case of amelanotic malignant melanoma showing the appearance of granuloma telangiectaticum

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  • 毛細血管拡張性肉芽腫の外観を呈した無色素性悪性黒色腫の1例

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A 40-year-old woman visited a dermatological clinic in summer, 2007 because of a red nodule bleeding easily on her left forearm. Granuloma telangiectaticum was susupected, and she was referred to our hospital. On her initial visit, a physical examination revealed a red pedunculated nodular tumor, 8mm in diameter, on her left forearm. It was surgically removed. A histopathological examination revealed spindle or polygonal neoplastic cells with clear nuclei without melanin pigment. Immunohistochemically, the neoplastic cells were positive for MelanA, S-100 but negative for HMB-45 ; they were therefore diagnosed as amelanotic malignant melanoma.<br>Close inspection of the whole body, including CT and PET-CT, showed no metastasis. Further resection was made and right axillary-lymph-nodes were removed (tumor thickness 6.0mm, pT4bN1M0 : Stage IIIB). The patient received 4 courses of DAV-Feron therapy and no recurrence was found.[Skin Cancer (Japan) 2010 ; 25 : 124-127]

Journal

  • Skin Cancer

    Skin Cancer 25 (2), 124-127, 2010

    The Japanese Skin Cancer Society

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