A case of primary cutaneous extranodal NK/T-cell lymphoma resembling CD8-positive primary cutaneous peripheral T-cell lymphoma (No period is necessary.)

DOI 7 References
  • NUMATA Shigeki
    Department of Dermatology, Fujita Health University School of Medicine
  • IWATA Yohei
    Department of Dermatology, Fujita Health University School of Medicine
  • OKAMOTO Masataka
    Department of Haematology, Fujita Health University School of Medicine
  • 山本 幸也
    Department of Haematology, Fujita Health University School of Medicine
  • 稲熊 容子
    Department of Haematology, Fujita Health University School of Medicine
  • MIZOGUCHI Yoshikazu
    Department of Diagnostic Pathology, Fujita Health University School of Medicine
  • MATSUNAGA Kayoko
    Department of Dermatology, Fujita Health University School of Medicine

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Other Title
  • CD8陽性末梢性T細胞リンパ腫と鑑別を要した皮膚原発節外性NK/T細胞リンパ腫，鼻型の1例

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Description

A 62 year-old man had recognized annular erythemas on the trunk and limbs which lasted for 2 months. Because a skin biopsy revealed CD8 positive peripheral T-cell lymphoma, he was referred to our hospital. On the initial consultation in our department, annular erythemas and tumors were present on the whole body surface. The abnormal cells were not found in the peripheral blood. Abnormal FDG avid lesions were not found by PET-CT scan, except for the skin. CHOP therapy was started on the initial diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). In an additional examination, tumor cells were positive for CD56 and Epstein-Barr virus encoded RNA (EBER) in situ hybridization. The TCR gene rearrangement was negative by Southern blot hybridization method. Therefore the patient was finally diagnosed with primary cutaneous extranodal NK/T cell lymphoma (ENKL). CHOP therapy was not effective ; therefore we switched to SMILE therapy which consists of steroid ; dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide that gave a complete response after 2 courses. Our case showed that differentiation of primary cutaneous ENKL was necessary for the case doubted a CD8-positive PTCL-NOS.[Skin Cancer (Japan) 2014 ; 29 : 258-263]

Journal

  • Skin Cancer

    Skin Cancer 29 (3), 258-263, 2015

    The Japanese Skin Cancer Society

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