A case of amelanotic malignant melanoma in a patient with Oculocutaneous albinism

DOI 2 References
  • AIZAWA Atsuko
    Department of Dermatology, Niigata University School of Medicine
  • KABUMOTO Takenori
    Department of Dermatology, Niigata University School of Medicine
  • ORIME Mari
    Department of Dermatology, Niigata University School of Medicine
  • ASANO Yukie
    Department of Dermatology, Niigata University School of Medicine
  • MATSUYAMA Asako
    Department of Dermatology, Niigata University School of Medicine
  • FUJIWARA Hiroshi
    Department of Dermatology, Niigata University School of Medicine
  • ITO Masaaki
    Department of Dermatology, Niigata University School of Medicine
  • MIIDA Hiroshi
    Division of Dermatology, Shibata Prefectural Hospital

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Other Title
  • 眼皮膚白皮症患者に発生した無色素性悪性黒色腫の1例

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We report a case of a 56-year-old woman with amelanotic malignant melanoma. She had been diagnosed as suffering from oculocutaneous albinism (OCA) since her birth. A red nodule on her left thigh was recognized on the lesion since 3 months before her first visit on our hospital. Histological findings of the lesion revealed a massive proliferation of atypical tumor cells in the nodule with invasion into the mid-dermis. We diagnosed it as amelanotic malignant melanoma, because the tumor cells were positively stained by HMB45, melanA, S100protein and Fontana- Masson stainings. It was confirmed by gene search that she suffered from type I of OCA. The malignant melanoma area was broadly excised. At the present time, she has been treated with local injections of IFN-β. OCA patients often develop skin cancers such as squamous cell carcinoma and basal cell carcinoma, but it is rare that they develop malignant melanoma.[Skin Cancer (Japan) 2014 ; 29 : 58-62]

Journal

  • Skin Cancer

    Skin Cancer 29 (1), 58-62, 2014

    The Japanese Skin Cancer Society

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