Cutaneous T-cell lymphoma with petechiae

DOI 4 References
  • FUJII Noriko
    <i>Department of Dermatology, Tokyo Medical University Hachioji Medical Center</i>
  • NAGATANI Tetsuo
    <i>Department of Dermatology, Tokyo Medical University Hachioji Medical Center</i>
  • TANI Mamoru
    <i>Department of Dermatology, Osaka University</i>

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  • 点状出血斑を伴うT細胞皮膚リンパ腫の1例

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A 19-year-old male patient first noticed asymptomatic erythema with petechiae covering the whole body at the age of 11, which expanded in size one year prior to his visit. Histological examination found infiltration of various cells, including small lymphocytes in the epidermis, and perivascular infiltration of small lymphocytes with an apparently notched nucleus, large, atypical lymphocytes and histiocytes in the dermis. Extravasation of erythrocytes from blood vessels was also found. Immunohistochemical analysis indicated a large proportion of CD3, CD4, and CLA-positive cells, as well as dissemination of CD30 and granzymeB-positive cells. Immunostaining was negative for TIA-1 and ALK, and monoclonal rearrangement of the T-cell receptor was not detected. The absence of Pautrier microabscesses and mycosis cells in the epidermis ruled out the diagnosis of mycosis fungoides and large cell transformation. The infiltrated cells were various and included small lymphocytes, large atypical cells, and histiocytes, while the immunohistochemistry was similarly diverse. Low positivity for CD30 ruled out the diagnosis of primary cutaneous anaplastic large cell lymphoma, while the clinical findings were not consistent with LyP. On the basis of these observations, we made the diagnosis of cutaneous T-cell lymphoma with petechiae.[Skin Cancer (Japan) 2013 ; 28 : 98-102]

Journal

  • Skin Cancer

    Skin Cancer 28 (1), 98-102, 2013

    The Japanese Skin Cancer Society

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