書誌事項
- タイトル別名
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- A Case Report of Neonatal Alloimmune Thrombocytopenia Associated with Maternal Anti-HPA-5b Antibody
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We report a case of neonatal alloimmune thrombocytopenia (NAIT) associated with antibody directed against human platelet antigen (HPA) -5b. A female infant was transferred to our neonatal intensive care unit (NICU) on the first day of life because of smallness for date. The blood examination on admission showed thrombocytopenia without bleeding tendency. The screening for antibodies against HPA by a mixed passive hemagglutination (MPHA) procedure showed that the sera of her mother contained an antibody which reacted with the infant's and her father's platelets. Anti-HLA antibodies were not detected in either the serum of the infant or the mother, but a specific anti-HPA-5b was found in the mother's serum. Genotyping by polymerase chain reaction (PCR) -LuminexTM applied to HPA genes showed that the mother was the homozygote of HPA-5a and that the infant and father were the heterozygotes of HPA-5a and HPA-5b. The diagnosis of NAIT associated with the maternal anti-HPA-5b antibody was made. Thenumbers of platelets of the infant were above 15.0 × 104/μl without remarkable event at 15 days of age. Wediscuss the characteristics of this disease in the Japanese population and the antenatal and postnatal management.
収録刊行物
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- 日本小児血液学会雑誌
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日本小児血液学会雑誌 22 (4), 239-242, 2008
特定非営利活動法人 日本小児血液・がん学会
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詳細情報 詳細情報について
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- CRID
- 1390282679317540096
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- NII論文ID
- 130004345993
- 10029309515
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- NII書誌ID
- AN10080852
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- ISSN
- 18844723
- 09138706
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可