Clinical significance of serum MMP-3 in rheumatoid arthritis

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  • Yasuda Tomohiro
    Department of Orthopedic surgery, Fujigaoka Hospital, Showa University School of Medicine
  • Obara Shu
    Department of Orthopedic surgery, Fujigaoka Hospital, Showa University School of Medicine

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  • 関節リウマチにおける血清MMP-3値の臨床的意義

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It is thought that serum levels of MMP-3 reflects synovial inflammation. However, it is our experience that discrepancy occurs in the case of evaluation of inflammatory activity in RA. The objective of this study is to investigate clinical features of serum levels of MMP-3. We investigated the 46 patients with RA who fulfilled the 1987 criteria of the American Rheumatism Association, and who were treated at the Department of Orthopedic Surgery, Fujigaoka Hospital, Showa University School of Medicine. There were 9 males and 37 females, aged from 41 to 76 years (average 59.5 years). Steinbrocker RA stage was I in 14 patients, II in 16, III in 11, IV in 5. Useof MTX was 5.6 mg/dl on average, and administered to 41 patients (89.1%). Use of corticosteroids was 3.1 mg/dl on average, and administered to 35 patients (76.1%).<br>     We measured, DAS28-CRP, CRP, tender joints count, swollen joints count, and VAS, and investigated their relation with serum levels of MMP-3. Serum levels of MMP-3 and the values of CRP, tender joints count, swollen joints count, DAS28-CRP showed correlation. A correlation coefficient more than 0.4 was only found for the swollen joints count. The correlation between serum levels of MMP-3 and DAS 28-CRP was not strong.

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