An autonomous drug-injection system with chemo-mechanical energy conversion "Organic Engine"

DOI 2 References Open Access
  • HATAYAMA Koudai
    Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • KATO Ryodai
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • MUNKHBAYAR Munkhjargal
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • MATSUURA Yuki
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • TAKAHASHI Daishi
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • ARAKAWA Takahiro
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • KUDO Hiroyuki
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • MITSUBAYASHI Kohji
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

Bibliographic Information

Other Title
  • 化学‐力学エネルギー変換（有機エンジン）を用いた自律駆動型薬物放出システム

Description

A novel drug-injection system that utilities direct chemo-mechanical energy conversion was fabricated and demonstrated for feedback control of glucose level. The system consists of two integrated units, decompression unit and drug release unit. The decompression unit was fabricated by separating a cylindrical cell into a top cell (gas phase) and a bottom cell (liquid phase) by glucose oxidase (GOD) enzyme immobilized membrane. The enzyme membrane recognizes glucose and converts chemical energy into pressure decreaese by consuming oxgen. The linear correlation between glucose concentration and de-pressure slope of the top cell was revealed as applying glucose solution to the bottom cell. The drug release unit which utilizes the energy of the decompression unit as a power source was evaluated by recording its release actions. The system is expected to be used in intelligent actuators without external energy.

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Details 詳細情報について

  • CRID
    1390282679319089920
  • NII Article ID
    130004837652
  • DOI
    10.2978/jsas.22.34
  • ISSN
    18813917
    09155651
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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