A Successful Bone Marrow Transplantation for Secondary Acute Lymphoblastic Leukemia in a Child Treated for Wilms' Tumor.

KAI Sumio, TAKAHASHI Hiroyuki, SEKIGUCHI Haruyuki, IKUTA Koichiro, SASAKI Hideki, MATSUYAMA Shusuke, MIZUTANI Shumpei

doi:10.11412/jjph1987.7.75

Bibliographic Information

Other Title

ウィルムス腫よう治療後に発症し，第二寛解期に骨髄移植を施行した急性リンパ性白血病の１例

Abstract

We report here secondary acute lymphoblastic leukemia (ALL) in a child previously treated for Wilms' tumor. A 4-year-old female presented in January 1985 with anorexia and a left abdominal mass. The diagnosis of Wilms' tumor was confirmed after total excision. She was treated with radiation and chemotherapy using actinomycin D, vincristine and vindesine for 15 months. In May 1988, the patient developed intermittent fever and hepatomegaly. Bone marrow aspiration was consistent with acute lymphoblastic leukemia. Complete remission occurred after chemotherapy with prednisolone, vincristine, L-asparaginase and daunorubicin, but relapse developed in June 1990. The patient responded well to the second remission-induction therapy, and underwent an allogeneic bone marrow transplantation from HLA identical younger sister in January 1991. She remains free of recurrent disease. While myelogenous leukemia is a common second malignancy following the treatment of Wilms' tumor, ALL is rare. It is said that secondary ALL has poor prognosis. Hence, we believe that bone marrow transplantation should be firstly considered for the treatment of secondary ALL.

Journal

The Japanese Journal of Pediatric Hematology

The Japanese Journal of Pediatric Hematology 7 (1), 75-79, 1993

THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY

Keywords

Details 詳細情報について

CRID: 1390282679319301632

NII Article ID: 130004346186

DOI: 10.11412/jjph1987.7.75

ISSN: 18844723; 09138706

Text Lang: ja

Data Source

JaLC
CiNii Articles

Abstract License Flag: Disallowed

Export