The analysis of anti-CCP antibodies in psoriasis with arthritis

DOI 1 Citations
  • Yamamoto Motohisa
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Ohara Mikiko
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Suzuki Chisako
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Naishiro Yasuyoshi
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Yamamoto Hiroyuki
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Takahashi Hiroki
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Shinomura Yasuhisa
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • Imai Kohzoh
    Sapporo Medical University

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  • 関節症状を有する乾癬症例における抗CCP抗体の有用性の検討

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Abstract

    Psoriasis is an autoimmune and chronic skin disease. There are about 100, 000 patients with psoriasis in Japan. Six percent of these patients suffer arthralgia. Rheumatologists have to discriminate between the complicated cases with rheumatoid arthritis and psoriatic arthritis because rheumatoid arthritis is rapid and severe joint destructive disease and is coupled with systemic complications such as rheumatoid nodule, interstitial pneumonia and vasculitis.<br>     We examined the utility of the anti-CCP antibodies in eleven patients with psoriasis complicated by arthritis. Clinical diagnosis followed for psoriatic arthritis by the definition reported by Moll and Wright (1973) and rheumatoid arthritis by the criteria of American College of Rheumatology (1987). All was diagnosed as psoriatic arthritis and three patients with rheumatoid arthritis. It was disclosed that the sensitivity of anti-CCP antibodies in rheumatoid arthritis was 66.7%, and the specificity was 100.0% in this study.<br>     We also analyzed the clinical characteristics in the anti-CCP antibodies-positive and negative group. The values of CRP and MMP-3 in the anti-CCP antibodies positive-cases were revealed to be higher than in the negative group. The anti-CCP antibodies positive group showed multiple bone erosions.<br>     It is possible that an anti-CCP antibody was one of the factors in predicting joint destruction, irrespective of complication by rheumatoid arthritis.

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