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Analysis of ten childhood cases which correspond to the criteria of ill-defined dyshematopoiesis.
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- KAWAUCHI Kyoichi
- Department of Pediatrics, Hirosaki University School of Medicine
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- ITOH Ryousuke
- Department of Pediatrics, Hirosaki University School of Medicine
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- MIYANO Takakazu
- Department of Pediatrics, Hirosaki University School of Medicine
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- KITAZAWA Junnichi
- Department of Pediatrics, Hirosaki University School of Medicine
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- SUDO Yoshimasa
- Department of Pediatrics, Hirosaki University School of Medicine
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- KASAI Mikio
- Department of Pediatrics, Hirosaki University School of Medicine
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- ARAI Kouji
- Department of Pediatrics, Hirosaki University School of Medicine
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- ECHIZENYA Taketora
- Department of Pediatrics, Hirosaki University School of Medicine
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- SATO Yuichi
- Department of Pediatrics, Hirosaki University School of Medicine
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- YOKOYAMA Masaru
- Department of Pediatrics, Hirosaki University School of Medicine
Bibliographic Information
- Other Title
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- Ill‐defined dyshematopoiesisの概念に合致すると考えられた10例の検討
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Description
Since the myelodysplastic syndrome (MDS) usually occurs with elderly patients, there have been few reports describing the syndrome during the childhood period. But recently, pediatric hematologists clearly recognize that MDS is less rare than was previously thought. Childhood MDS is diagnosed on the classification of the French-America-British Cooperative Study Group (FAB) but we still have such cases with hematopoietic dysplasia which are difficult to classify by the FAB system. The classification of ill-defined dyshematopoiesis has not been widely accepted yet but is considered to be very useful to observe and treat patients with unexplainable cytopenias. We reported ten childhood cases that correspond to the criteria of ill-defined dyshematopoiesis and analyzed their hematological features. Six patients out of ten developed leukemia after four months to nine years. Elevated serum levels of LDH (above 400 IU/l) and especially elevated LDH II ratio at the onset may be a factor for predicting leukemia development. More data regarding the MDS and ill-defined dyshematopoiesis in children is obviously needed.
Journal
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- The Japanese Journal of Pediatric Hematology
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The Japanese Journal of Pediatric Hematology 4 (2), 140-146, 1990
THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY
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Details 詳細情報について
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- CRID
- 1390282679319662336
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- NII Article ID
- 130004118004
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- ISSN
- 18844723
- 09138706
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed