Clinical Manifestations and Pathogenesis in 5 Cases of Idiopathic Pulmonary Hemosiderosis.

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  • TAKAHASHI Koichi
    Department of Pediatrics and Child Health, Kurume University School of Medicine
  • EGUCHI Haruhiko
    Department of Pediatrics and Child Health, Kurume University School of Medicine
  • SHIMIZU Takashi
    Department of Pediatrics and Child Health, Kurume University School of Medicine
  • INADA Hiroko
    Department of Pediatrics and Child Health, Kurume University School of Medicine
  • ANDO Akikazu
    Department of Pediatrics and Child Health, Kurume University School of Medicine
  • ICHTKAWA Kotaro
    Department of Pediatrics, Kitakyushu City Yahata Hospital

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Other Title
  • 特発性肺ヘモジデローシス５例の臨床像および病因論の考察

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We herein describe 5 children (1 boy, 4 girls) who were diagnosed with idiopathic pulmonary hemosiderosis (IPH) during these 10 years. The age of onset ranged from 11 months to 3 years. The first symptoms of all children were fever and anemia, however one child complained of hemoptysis. With the exception of one child, there were respiratory symptoms at the onset of IPH in all cases. Blood transfusions were needed in 3 children, all of whom died within 6 months after onset, and 2 others are alive. Four children had various perinatal abnormalities, and 3 of them received mechanical ventilation. Barotrauma due to mechanical ventilation may cause the alveolar epithelial alterations. We suggest that in our cases, these alterations may be one of the pathogenic mechanisms of IPH.

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