A clinical study on 45 cases of intraoral minor salivary gland carcinoma

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  • Tanaka Kae
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • Omura Ken
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • Harada Hiroyuki
    Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
  • Okada Norihiko
    Department of Diagnostic Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

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  • 口腔内小唾液腺癌45例の臨床的検討

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Abstract

We analyzed the clinical features of 45 patients with intraoral minor salivary gland carcinoma treated at our department between April 2001 and March 2011.<br>The buccal mucosa was the most common site accounting for 13 cases, followed by the floor of the mouth in 8 cases. Of the 45 cases, 16 cases were classified as stage I, 13 as stage II, 3 as stage III, 12 as stage IVA, and 1 as stage IVB. Histologically, mucoepidermoid carcinoma (MEC) was the most common disease (n=22), followed by adenoid cystic carcinoma (ACC) (n=13) and polymorphous low-grade adenocarcinoma (n=4).<br>Forty-four patients underwent radical surgery and one patient received irradiation as the initial treatment. Local recurrence developed in 4 cases of MEC and each case of ACC and adenocarcinoma, NOS. These four MECs consisted of 2 (40.0%) high grade malignancies and one case each of intermediate (20.0%) and low grade malignancy (9.1%), both of which except for the high grade MECs were salvaged by additional surgery. Neck failure following neck dissection performed on 16 cases occurred in one case each of high and intermediate grade MEC, and the latter was salvaged by additional surgery. Lung metastasis occurred in 3 cases of ACC, resulting in death without locoregional disease. Five-year and 10-year disease-specific survival rates were 90.1% and 66.9%.<br>These results suggest that radical surgery is needed for local control of high grade MEC, and the treatment modality should be developed for lung metastasis in ACC.

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