A Case of Medullary Intracystic Breast Carcinoma

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  • 嚢胞内乳癌の形態をとった乳腺髄様癌の１例

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We report a case of intracystic medullary breast carcinoma. A 40–year–old woman seen for mild left breast pain was found to have a soft elastic flat mass of 6 cm above the left nipple. Mammography showed a dense well–defined tumor and ultrasonography a cystic lesion. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a defined 4 cm cystic lesion with a mural nodule. Fine–needle aspiration cytology indicated adenocarcinoma necessitating partial left breast resection definitively diagnosed as intracystic carcinoma. The resected specimen showed a cystic lesion with a papillary mural nodule. Histopathology showed medullary carcinoma with microinvasive atypical cell foci to the wall. Immunostaining showed cancer cells to be negative for antiestrogen receptor and progesteron receptor antibodies and HER2/neu protein. Postoperative irradiation and adjuvant chemotherapy (5FU, epirubicin, cyclophosphamide) have left the woman disease–free 13 months postoperatively.

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