A case of mucin producing bile duct tumor resembling intraductal papillary mucinous neoplasm of the pancreas

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  • 膵のIPMN様の病理形態を呈した粘液産生胆管腫瘍の1例

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A 56-year-old man with epigastric pain was admitted to our hospital. Laboratory date showed elevated levels of liver and biliary enzymes, but US and MRCP showed no evidence of mass lesions. CT reveled slight dilatation of the left intahepatic bile duct. After 2 months, US and CT recognized severe dilatation of the left intahepatic bile duct. PTC showed stenosis of bifurcation of it and filling defect. These findings suggested cholangiocarcinoma, and we underwent left lobectomy. The resected specimen showed stenosis of it, and mucin clot in peripheral bile duct. Histopatological examination of the stenotic lesion revealed a noninvasive tumor composed of low papillary, mucin-producing neoplastic epithelium with borderline malignancy. Immunohistochemically, the neoplastic epithelium was positive for MUC5AC and MUC2, and partly positive for MUC6, but negative for MUC1. The tumor was diagnosed as a mucin producing bile duct tumor, which pathological features resembled those of intestinal type of intraductal papillary mucinous neoplasm of the pancreas.

Journal

  • Tando

    Tando 22 (4), 518-523, 2008

    Japan Biliary Association

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