Evaluation of efficacy of Fexofenadine/Pseudoephedrine combination tablet on patients with perennial allergic rhinitis: Evaluation by rhinomanometry

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  • Nakamura Yosuke
    Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Tottori University
  • Takeuchi Hiromi
    Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Tottori University
  • Fukushima Kei
    Department of Otolaryngology, Head and Neck Surgery, National Hospital Organization Fukuyama Medical Center
  • Yokoyama Yuko
    Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Tottori University
  • Morizane Rie
    Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Tottori University
  • Enomoto Tadao
    NPO Japan Promotion Supporting Network

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Other Title
  • フェキソフェナジン塩酸塩/塩酸プソイドエフェドリン配合錠単剤投与の鼻閉に対する効果
  • ―鼻腔通気度検査による評価―

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<p>Background: A Fexofenadine/Pseudoephedrine combination tablet (F/P) is a novel product containing fexofenadine hydrochloride, a histamine H1-receptor antagonist for sneezing and rhinorrhea and pseudoephedrine hydrochloride, an α adrenergic agonist for nasal obstruction. The effect to the nasal obstruction of the F/P is confirmed empirically. But, there are few reports that the effect of the F/P to nasal obstruction was considered objectively. In the present study, we estimated the efficacy of the drug on nasal obstruction for patients with allergic rhinitis.</p><p>Method: Seventeen subjects (12 males and 5 females, aged 16–47 years) with perennial allergic rhinitis were recruited for the study. Each subject was measured for the patency by anterior rhinomanometry and the sensation of it by Visual Analogue Scale (VAS) scores. Nasal airflow and VAS scores were recorded at 30 minute intervals for 4 hours before dosing and for 8 hours after dosing as a single drug therapy. The efficacy was onset of action, assessed in terms of absolute change from baseline before dosing.</p><p>Result: Subjects’ mean age was 28.6 and 70.6% were male. The onset of action of F/P was 1.5 hours, significant improvement in nasal airflow from baseline was detected with the mean change of 79.4 cm3/s (90% CI, 51.4–107.4; p=0.001). All subsequent changes from baseline in nasal airflow were statistically significant for F/P. The absolute in VAS scores were decreased at all time points from 2 hours after administering.</p><p>Conclusion: In this study, we found out that F/P is effective about an immediate effect and the continuation to nasal obstruction of perennial allergic rhinitis.</p>

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