インテリジェントヒーターを用いた網膜芽細胞腫治療装置の開発に関する研究（第一報）　境界要素法によるリアルタイム眼球断面温度分布推定

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  • The use of an intelligent heater in retinoblastoma therapy device (I). Estimating the temperature distribution in eyeball cross section using the boundary element method.
  • Estimating the temperature distribution in eyeball cross section using the boundary element method
  • 境界要素法によるリアルタイム眼球断面温度分布推定

抄録

Retinoblastoma is a hereditary malignant tumor, mostly occurring in infants and children. Although the common treatment is the surgical extraction of eyeball, non-invasive several methods such as chemotherapy, irradiation, and hyperthermia therapy using microwave are conducted as treatments for the disease. The hyperthermia therapy using microwave tends to heat the optic nerve excessively. Therefore an intelligent heater was developed to prevent the above problem. The surface temperature of the intelligent heater was automatically maintained at constant temperatures when the room temperature or the applied voltage was changed. The intelligent heater showed the positive temperature coefficient (PTC) effect. It has conductive carbon-black distributed by grafting of polyethylene glycol as crystalline polymer. The intelligent heater reduces the risk of excessive heating of the optic nerve, because the material itself controls the temperature. Real time evaluation of the temperature distribution in cross section of the eyeball phantom was carried out using the boundary-element method. The surface temperature of the agar phantom imitating eyeball was measured as boundary conditins. The calculated temperature of the imitated eyeball phantom at the mid-point was compared with the measured temperature at thermal equilibrium. The calculated temperature approximately agreed with the measured temperature. The non-invasive temperature estimation of an imitated eyeball cross section was achieved using the boundary-element method. This device appears promising for its safe clinical applications in hyperthermic retinoblastoma therapy.

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