Spectrophotometric determination of chlorpheniramine maleate by solvent extraction with zincon

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  • ジンコンを用いての溶媒抽出によるマレイン酸クロルフェニラミンの比色定量法
  • ジンコン オ モチイテ ノ ヨウバイ チュウシュツ ニヨル マレインサン クロ

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A spectrophotometric method for the determination of chlorpheniramine maleate (MCP) by solvent extraction with zincon has been established. MCP is extracted as a 1 : 1 ion association complex with zincon in the organic phase, and determined by measuring absorbance of the extract at 530 nm. The absorbance of the extract showed to be linear over the concentration range of (1.0×10-51.0×10-4) M MCP in aqueous solution. Assay method is as follows: One ml of a sample solution containing (1.05.0)×10-4 M MCP is taken in a test tube and 5 ml of acetate (0.1 M) buffer (pH 4.6), 1 ml of zincon solution (1.0×10-3 M) and 3 ml of water are added. This solution is shaken with 5 ml of dichloromethane for 3 min. The extract is filtered through a dry filter paper to remove water. The absorbance is measured at 530 nm against either a reagent blank or water. The method proposed has high sensitivity and is applicable to the determination of MCP in drug preparations.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 27 (11), 707-711, 1978

    The Japan Society for Analytical Chemistry

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