ガスクロマトグラフィーによるアミン及びアミノ酸光学異性体分離用の新しい固定相としてのジペプチドエステルのs-トリアジン誘導体

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タイトル別名
  • 光学異性体の分析に関する研究　ＩＩＩ　　ガスクロマトグラフィーによるアミン及びアミノ酸光学異性体分離用の新しい固定相としてのジペプチドエステルの?Eｓ?F‐トリアジン誘導体
  • <I>s</I>-Triazine derivatives of dipeptide esters as novel stationary phases for the separation of amine and amino acid enantiomers by gas chromatography
  • ガス クロマトグラフィー ニヨル アミン オヨビ アミノサン コウガク イセイ
  • 光学異性体の分析に関する研究(第3報)

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抄録

Although N-acyl dipeptide esters are useful as the optically active stationary phases for the gas chromatographic separation of amino acid enantiomers, these phases are not very effective for the separation of amine enantiomers, and moreover, their thermally stable range is limited. In order to overcome these disadvantages, we have newly synthesized two s-triazine derivatives of dipeptide esters; N, N'-[2, 4-(6-ethoxy-1, 3, 5-triazine)diyl]-bis-(L-valyl-L-valine isopropyl ester) [I] and N, N'-[2, 4-(6-cyclohexylamino-1, 3, 5-triazine)-diyl]-bis-(L-valyl-L-valine isopropyl ester) [II]. These new phases were able to separate both amino acid and amine enantiomers quite effectively. It was noticed that higher separation factors were obtained on [I] than on the corresponding s-triazine derivatives of amino acid esters, N, N', N″-[2, 4, 6-(1, 3, 5-triazine)-triyl]-tris-(L-valine isopropyl ester) [III]. For example, the separation factors (α) for N-TFA-DL-valine isopropyl ester were 1.055 on [I] and 1.047 on [III] at 110°C, and for N-PFP-dl-α-(1-naphthyl)ethylamine were 1.061 on [I] and 1.039 on [III] at 150°C. [I] and [II] show high thermal stability, and their maximum permissible operation temperatures were about 170°C and 175°C, respectively. Moreover, due to their relatively low melting points {(7172)°C and (103104)°C, respectively}, their columns are effective over a wide range of temperature.

収録刊行物

  • 分析化学

    分析化学 28 (2), 69-72, 1979

    公益社団法人 日本分析化学会

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