Development of Residue Analysis for Pesticides by LC/MS and LC/MS/MS Methods

Kobayashi Hiroko

doi:10.2116/bunsekikagaku.58.985

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Other Title

液体クロマトグラフィー／質量分析及び液体クロマトグラフィー／タンデム質量分析法による残留農薬分析
エキタイクロマトグラフィーシツリョウブンセキオヨビエキタイクロマトグラフィータンデムシツリョウブンセキホウニヨルザンリュウノウヤクブンセキ

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Description

Some agricultural chemicals having high polarity, low vapor pressures or high thermal instability are not directly amenable to GC and GC/MS. We established new analytical methods using LC/MS and LC/MS/MS for such agricultural chemicals as pyrethroids, neonicotinoids and guanidines. The analytical method of a pyrethroid insecticide, tralomethrin, using gas chromatography (GC) with electron-capture and mass spectrometry (MS) detectors is to measure the deltamethrin transformed from tralomethrin in the injector port of the GC system. By using LC/MS, however, both pesticides could be separated and determined simultaneously. Although gas chromatography (GC) and high-pressure liquid chromatography with fluorescence (HPLC-FL) have been used for guanidino pesticides determination, a derivatization step is usually required. Moreover, guanidino pesticides that easily adsorb sample matrixes could also be analyzed by using LC/MS without a derivatization step. In the case of nitenpyram, a neonicotinoid pesticide, its metabolites have been determined by GC after derivatization. However, ten compounds including the metabolites could be simultaneously and selectively analyzed by using LC/MS/MS. In addition, the effect of additives on the extraction efficiency, an important factor for the analytical method, could be outlined.

Journal

BUNSEKI KAGAKU

BUNSEKI KAGAKU 58 (12), 985-997, 2009

The Japan Society for Analytical Chemistry

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