ガスクロマトグラフィー及びポーラログラフィーによるネライストキシンとネライストキシンモノオキシドとの分別定量法

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タイトル別名
  • Gas chromatographic and polarographic determination of nereistoxin and nereistoxin monoxide
  • ガス クロマトグラフィー オヨビ ポーラログラフィー ニヨル ネライストキシン

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抄録

Nereistoxin monoxide (4-dimethylamino-1, 2-dithiolane 1-oxide) and nereistoxin (4-dimethylamino-1, 2-dithiolane) which were considered to be metabolites of cartap hydrochloride {2-dimethylaminotrimethylene S, S'-bis (thiocarbamate) hydrochloride} in soil and plant tissue, were determined by gas chromatography (GC) and polarography. On GC analysis, nereistoxin monoxide and nereistoxin dissolved in acetic acid-methanol were directly injected since nereistoxin monoxide is stable in acidic solution. The minimum detection amount of nereistoxin monoxide and nereistoxin with a FPD was as low as 1 ng. Nereistoxin monoxide in acidic solution showed a fourelectron reduction wave due to the formation of thiosulfinate accompanied with an adsorption wave on polarography. Nereistoxin monoxide was easily hydrolyzed in alkaline solution to give 2-dimethylamino-3-mercaptopropanesulfinic acid (DMSA) and the reduction wave disappeared. DMSA showed an anodic wave due to the formation of mercaptide accompanied with an adsorption wave and the wave height is proportional to the concentration. Nereistoxin monoxide and nereistoxin were determined separately by the anodic wave (E1/2=-0.30 V vs. SCE) from DMSA and the reduction wave (E1/2=-0.52 V vs. SCE) after the hydrolysis of the mixture since nereistoxin was stable in alkaline solution. The hydrolysis of nereistoxin monoxide in aqueous solution was base-catalyzed pseudo-first reaction within pH 812. The half-life (t1/2) of this compound at pH 10.5 was 10 min at 25°C.

収録刊行物

  • 分析化学

    分析化学 28 (3), 137-142, 1979

    公益社団法人 日本分析化学会

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