高速液体クロマトグラフィーによる総合感冒剤中の鎮がい剤,きょたん剤及び抗ヒスタミン剤の定量

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書誌事項

タイトル別名
  • 高速液体クロマトグラフィーによる混合製剤の分析　ＩＩ　　高速液体クロマトグラフィーによる総合感冒剤中の鎮がい剤，きょたん剤及び抗ヒスタミン剤の定量
  • Determination of antitussive, expectorant and antihistaminic in anti-cold preparations by high-speed liquid chromatography
  • コウソク エキタイ クロマトグラフィー ニヨル ソウゴウ カンボウザイチュウ
  • 高速液体クロマトグラフ法による混合製剤の分析(第2報)

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説明

The rapid, sensitive, and specific high-speed liquid chromatographic method for the quantitative analysis of antitussive, expectorant and antihistaminic in anti cold preparations was established. Diphenhydramine salicylate, diphenhydramine hydrochloride, tipepidine citrate and alloclamide hydrochloride were separated by injection of methanol solution on to a column (3φ×50 cm) packed with styrene-divinyl benzene porous polymer (Hitachi Gel 3011). Diphenhydramine and tipepidine were eluted with a mixture of methanol and 28% ammonia water (99:1) and alloclamide with a mixture of methanol, water and 28% ammonia water (95:3:2), and all of them were detected at 230 nm. Noscapine, alimemazine tartrate, promethazine methylenedisalicylate and isothipendyl hydrochloride were separated by injection of methanol solution on to column (3φ×50 cm) packed with hydroxyethylated styrene-divinyl benzene porous polymer (Hitachi Gel 3011-O), eluted with a mixture of methanol and 28% ammonia water (99:1), and detected at 230 nm or 250 nm, respectively. Dextromethorphan hydrochloride were separated by injection of a methanol solution on to a column (3φ×50 cm) packed with carboxylated styrene-divinyl benzene porous polymer (Hitachi Gel 3011-C), eluted with a mixture of methanol and 28% ammonia water, and detected at 230 nm. Other ingredient, such as acetaminophen, phenacetin, sulpyrine, aspirin, caffeine, ethoxy benzamide and methylephedrine hydrochloride, did not interfere with the analysis. The method is sensitive and accurate for analysis of antitussive, expectorant, and antihistaminic in anti-cold preparations.

収録刊行物

  • 分析化学

    分析化学 26 (10), 706-711, 1977

    公益社団法人 日本分析化学会

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