Development of NIR Fluorescence Bioimaging System through Polyscale Technology

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  • Soga Kohei
    Polyscale Technology Research Center (PTRC), Tokyo University of Science Department of Materials Science and Technology, Tokyo University of Science

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  • ポリスケールテクノロジーによる近赤外励起蛍光バイオイメージングシステムの開発
  • ポリスケールテクノロジー ニ ヨル キンセキガイレイキケイコウ バイオイメージング システム ノ カイハツ

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Abstract

Fluorescence bioimaging is one of the important technologies for biomedical applications to visualize phenomena in biological systems. Current problems of the bioimaging, such as color fading of phosphors, strong scattering and background illumination due to auto-fluorescence, are mostly caused by using short wavelengths for exciting fluorescence. To solve all of them, the authors have investigated an imaging system to use near-infrared light as an excitation source. For achieving this, rare-earth-doped ceramic nanophosphors are used to emit fluorescence efficiently. Collaboration concerning these technologies starting from the atomic scale, and reaching to the macroscopic scale through the nano scale is essential for the development of the system. In this review article, the development of a system using polyscale technologies is overviewed.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 58 (6), 461-471, 2009

    The Japan Society for Analytical Chemistry

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