開胸術後とう痛に対する胸腔内局麻剤注入法の効果について

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  • Effectiveness of interpleural analgesia in management of the post-thoracotomy Pain.

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To investigate the effectiveness of interpleural analgesia (IPA) in the management of post-thoracotomy pain, we compared the epidural anesthetic group with the epidural anesthetic and IPA combination group. We divided 33 post-thoracotomy patients into two groups. Epidural anesthetic was administered to one group of the patients (Epi group), and epidural anesthetic and IPA were combined in the other group (IPA group). Buprenorphine hydrochloride was used as the epidural anesthetic agent. A double lumen chest tube was used as an indwelling drainage tube, and 20 ml of 0.25% bupivacaine was injected into the pleural cavity through the double lumen chest tube in the IPA group. Pain was assessed by visual analog scale (VAS) and the Prince Henry pain score (PH). The concentration of plasma bupivacaine was measured before and after Epi/IPA administration.<BR>The severity of pain was significantly milder in the IPA group than the Epi group. The concentration of plasma bupivacaine started to increase soon after IPA administration, after reaching a maximum in one hour (0.95 ± 0.21, μ/ml), it gradually decreased, and did not reach a toxic level.<BR>These findings suggested that epidural anesthetic and IPA combination was an easy and effective way to manage of post-thoracotomy pain.

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