書誌事項
- タイトル別名
-
- Transferrin Saturation and Tissue Iron Concentration in Rats with High Dose of Ferric Citrate
- コウヨウリョウ ノ クエンサン ダイニテツ オ トウヨ シタ ラット ノ トランスフェリン ホウワリツ ト ゾウキ チュウテツ ノウド
この論文をさがす
抄録
In patients with a renal failure, control of the absorption of dietary phosphate is necessary to prevent hyperphosphataemia. Recently, it has been proposed that ferric citrate is used as a phosphate-binder for patients with renal failure. However, several recent studies have indicated that an accumulation of iron in liver causes cirrhosis and liver cancer. In the present study, we examined iron accumulation in tissues of rats administered a large amount of ferric citrate.<br>Male 4-week-old Wistar rats were fed AIN93G diet (basal diet) or the basal diet supplemented with 1.0 or 4.0% ferric citrate hydrate (FCH; iron content, 18.5%) for 4 weeks. Administration of 4.0% FCH significantly inhibited the rat growth. However, liver function and lipid metabolism were not influenced by the FCH administration. Fecal phosphorus excretion was dose-dependently increased by the FCH administration and serum phosphate was significantly lower in the 4% FCH group compared to the other two groups. Serum iron and transferrin saturation was dose-dependently increased by the FCH administration. In particular, transferrin saturation of the 4.0% FCH group was near 100%. Iron in the liver, kidney, spleen and femur were markedly increased by the FCH administration; in particular, the increase of the hepatic iron was proportional to the dietary iron concentration. In addition, hemosiderin was accumulated in the cytoplasm of liver. These results indicate that transferrin is saturated and siderosis is caused by oral administration of a large amount of ferric citrate.
収録刊行物
-
- Biomedical Research on Trace Elements
-
Biomedical Research on Trace Elements 24 (1), 23-30, 2013
日本微量元素学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679342660992
-
- NII論文ID
- 10031170833
-
- NII書誌ID
- AN10423256
-
- COI
- 1:CAS:528:DC%2BC3sXhtVKjt7rN
-
- ISSN
- 18801404
- 0916717X
-
- NDL書誌ID
- 024703893
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可