Association of serum copper/ zinc ratio with low-grade inflammation and low handgrip strength in elderly women

DOI Web Site 参考文献31件
  • Tsuboi Ayaka
    Postgraduate School of Food Sciences and Nutrition, Mukogawa Women's University
  • Watanabe Mayu
    Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University
  • Kazumi Tsutomu
    Postgraduate School of Food Sciences and Nutrition, Mukogawa Women's University Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University Research Institute for Nutrition Sciences, Mukogawa Women's University
  • Fukuo Keisuke
    Postgraduate School of Food Sciences and Nutrition, Mukogawa Women's University Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University Research Institute for Nutrition Sciences, Mukogawa Women's University

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High serum copper/ zinc ratio (CZR) has been shown to be associated with cardiovascular disease (CVD) and all-cause mortality in elderly Western population. However, these associations have not been extensively studied in elderly population of Asian origin. Associations with traditional and non-traditional risk factors for CVD were examined in 202 community-living elderly Japanese women. After adjustment for age, associations with handgrip strength, log high-sensitivity C-reactive protein (hsCRP) and TNF-αremained significant and association with leukocyte count became significant. In multiple regression analysis, log hsCRP and handgrip strength emerged as independent determinants of CZR (R2=0.172). In conclusions, high CZR was independently associated with higher hsCRP and lower handgrip strength in freely- and community-living elderly Japanese women. Systemic low-grade inflammation and lower total body muscle strengthen may contribute to elevated serum copper/zinc ratio in the elderly, and may represent important confounders of the relationship between the ratio and mortality in this population

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