The Continual Reassessment Method (CRM) and Related Topics—A Review. Part I: Understanding the CRM for Dose-Finding Studies.
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- Daimon Takashi
- Department of Mathematics, Hyogo College of Medicine
Bibliographic Information
- Other Title
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- 連続再評価法とその周辺（I）—連続再評価法とは—
- 連続再評価法とその周辺(1)連続再評価法とは
- レンゾク サイヒョウカホウ ト ソノ シュウヘン(1)レンゾク サイヒョウカホウ トワ
- The Continual Reassessment Method (CRM) and Related Topics^|^mdash;A Review. Part I: Understanding the CRM for Dose-Finding Studies.
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Abstract
A number of designs of phase I dose-finding trials have been developed. Algorithm-based designs such as standard 3 + 3 designs are easy to understand and implement since they do not require explicit model specification for a dose-toxicity relationship. On the other hand, model-based designs such as the continual reassessment method (CRM) (O’Quigley et al., 1990) have been proposed. The author will give a review of the CRM and its related topics. In particular, the author makes mention of some of the problems with 3 + 3 designs that have often been used in phase I dose-finding studies and gives a detailed description of ideas, concepts, theories, properties and issues in the CRM.
Journal
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- Japanese Journal of Biometrics
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Japanese Journal of Biometrics 33 (1), 1-29, 2012
The Biometric Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679345300224
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- NII Article ID
- 130002151415
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- NII Book ID
- AA11591618
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- DOI
- 10.5691/jjb.33.1
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- ISSN
- 21856494
- 09184430
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- NDL BIB ID
- 023998640
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed
