生理活性オリゴ糖の化学合成  ガングリオシドの系統的合成

  • Ishida Hideharu
    Department of Applied Bio-organic Chemistry, Gifu University
  • Kiso Makoto
    Department of Applied Bio-organic Chemistry, Gifu University

書誌事項

タイトル別名
  • Chemical Synthesis of Bioactive Oligosaccharides. Systematic Syntheses of Gangliosides.
  • ガングリオシド ノ ケイトウテキ ゴウセイ ガン エイゴ ゲンブン

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抄録

The chemistry of the ganglioside synthesis can be divided into three steps: 1) construction of oligosaccharide backbone, 2) introduction of sialic acid into the oligosaccharide backbone, and 3) coupling of the sialo-oligosaccharide and sphingolipid. In this text, the latter two topics are described, first, as the problems common to all gangliosides, and the first topic as the individual problems specific to each subclass of ganglioside.

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