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- Holst Otto
- Structural Biochemistry, Research Center Borstel, Center for Medicine and Biosciences
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- 橋本 雅仁
- 朝日大学歯学部
書誌事項
- タイトル別名
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- Chemical Structure of the Core Region of Lipopolysaccharides. An Update.
- リポ タトウ ノ コア リョウイキ ノ カガク コウゾウ サイシンバン ガン エイブン
この論文をさがす
説明
Lipopolysaccharides (LPS) are the endotoxins of Gram-negative bacteria and very well known for their immunological, pharmacological and pathophysiological effects displayed in eucaryotic cells and organisms. To date, much emphasis has been put on the elucidation of the chemical structures of LPS and on their relation, or that of substructures, to the various biological effects. The lipid part of LPS, the lipid A, was proven to represent the toxic principle of endotoxin. However, lipid A toxicity depends strongly on its structure, and is influenced by a second region of LPS, the core region, that is covalently linked to lipid A. Also, the core region possesses immunogenic properties. Therefore, complete structural analyses of the core region and the comparison of its structures with biological features of LPS are of high importance for a better understanding of LPS action, and one prerequesite for strategies aimed at the treatment of endotoxicosis. In the past, quite a number of structures of the core regions from various Gram-negative bacteria were published and summarized in several overviews. The present review adds to this knowledge those structures that were published between October 1998 and December 2001.
収録刊行物
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- Trends in Glycoscience and Glycotechnology
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Trends in Glycoscience and Glycotechnology 14 (76), 87-103, 2002
FCCA(Forum: Carbohydrates Coming of Age)
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詳細情報 詳細情報について
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- CRID
- 1390282679346079616
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- NII論文ID
- 130003454706
- 10012195438
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- NII書誌ID
- AA10995236
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- ISSN
- 18832113
- 09157352
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- NDL書誌ID
- 6146223
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可