Development of highly efficient and stereocontrolled <i>O</i>-glycosylation methodologies and its application to the construction of bacterial glycans

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  • グリコシル化の高効率立体制御法の開発と細菌由来糖鎖構築への応用
  • グリコシル化の高効率立体制御法の開発と細菌由来糖鎖構築への応用[含 英語文]
  • グリコシルカ ノ コウコウリツ リッタイ セイギョホウ ノ カイハツ ト サイキン ユライ トウサ コウチク エ ノ オウヨウ ガン エイゴブン
  • Development of highly efficient and stereocontrolled O-glycosylation methodologies and its application to the construction of bacterial glycans

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Glycosylations have been used repeatedly as the key reaction in the synthesis of oligosaccharides and polysaccharides, therefore both of efficiency and stereoselectivity of the glycosylations are important. There has been reported the construction of 1,2-cis glycoside found in various bioactive glycoconjugate glycans from eukaryotes as well as prokaryotes, although a few for the definite methodologies to construct stereoselectively. Approaching from both efficiency and stereoselectivity of the reactions, we developed various highly efficient and stereocontrolled O-glycosylation methodologies for the construction of 1,2-cis glycosides. We also showed that their 1,2-cis glycosylation methodologies have been applied to the stereoselective synthesis of various bacterial glycoconjugate glycans.<br>

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