書誌事項
- タイトル別名
-
- Pharmacokinetics Of Vancomycin In Patients Undergoing Continuous Hemodiafiltration
抄録
The pharmacokinetics of several drugs are drastically different in patients undergoing continuous hemodiafiltration (CHDF) than in subjects with normal kidney functions, because of drug removal by the filtration or dialysis, and disturbances of metabolism and excretion caused by the complicating organ failures. We performed pharmacokinetic analysis of vancomycin in four patients undergoing continuous hemodiafiltration who were under treatment with the drug. The concentration of vancomycin in the plasma was determined by fluorescence polarization immunoassay (FPIA). The results showed that thetotal body clearance of vancomycin was 12.25±0.85L/hr, elimination half-life was 14.0±0.56hr, respectively. We simulated a plasma concentration-time curve to evaluate the appropriate dose of vancomycin to maintain the effective plasma level, that is, 10.0μg/ml.The simulation suggested that 1.0g of vancomycin administered daily at the dose of 1.0g was sufficient to maintain an effective trough plasma level in patients undergoing continuous hemodiafiltration.
収録刊行物
-
- 日本救急医学会雑誌
-
日本救急医学会雑誌 14 (11), 739-744, 2003
一般社団法人 日本救急医学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679346527616
-
- NII論文ID
- 130003625898
-
- ISSN
- 18833772
- 0915924X
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可