A Dynamic Allocation Procedure to Enable to Achieve a Specific Proportion of Sample Sizes

DOI Web Site 11 References

Bibliographic Information

Other Title
  • 任意の症例構成比率を確保するための動的割付
  • ニンイ ノ ショウレイ コウセイ ヒリツ オ カクホ スル タメ ノ ドウテキ ワリツケ

Search this article

Abstract

We showed a dynamic allocation procedure to achieve a specified proportion of sample sizes among treatment groups not only within all patients, but also within patients with strata composed of centers and/or prognostic factors in randomized controlled clinical trials. This procedure allocates a patient to one of treatment groups that are within a pre-specified range from the best balance, as well as the treatment groups with the best balance. When target sample sizes of two treatment groups are the same, Zelen (1974) showed a restriction for a range of obtained sample sizes. Proposed method is an extension of Zelen's restriction to the case of different target sample sizes of more than two treatment groups. This method can introduce randomness into a dynamic allocation procedure keeping comparability among treatment groups.

Journal

References(11)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top