The Sweet Kiss of Death: A Link between Galectin-1, Glycosylation and the Generation of Immune Privilege

Rubinstein Natalia, Toscano Marta A., Ilarregui Juan M., Bianco Germán A., Rabinovich Gabriel A., 佐々木 洋子

doi:10.4052/tigg.17.133

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Other Title

死の甘いキス：ガレクチン‐１，糖鎖修飾，免疫特権生成をつなぐもの
シノアマイキスガレクチン 1 トウサシュウショクメンエキトッケンセイセイオツナグモノガンエイゴゲンブン
A Link between Galectin-1, Glycosylation and the Generation of Immune Privilege
ガレクチン-1、糖鎖修飾、免疫特権生成をつなぐもの

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Description

Galectin-1 (Gal-1), a member of a family of highly conserved carbohydrate-binding proteins, has been reported to be a potent immunosuppressive and anti-inflammatory factor. It has been proposed that the presence of galectin-1 in organs such as the eye, the placenta, reproductive organs (testis, ovaries) and also in tumours might confer a status of immune privilege to these vulnerable sites. Up-regulated expression of this protein may contribute to preserve an immunosuppressive microenvironment by inducing apoptosis of inflammatory and effector T cells and skewing the balance of the local immune response towards a Th2 cytokine profile. Different glycosyltransferase enzymes are involved in the generation of specific saccharide ligands required for Gal-1 binding and Gal-1-induced cell death. Interestingly, expression of these enzymes is highly regulated during T cell development, activation and apoptosis. The aim of this review is to explore the potential link between glycosylation of immune cell subsets, susceptibility to Gal-1 and the generation of immune privilege, particularly in the context of tumor-immune escape.

Journal

Trends in Glycoscience and Glycotechnology

Trends in Glycoscience and Glycotechnology 17 (96), 133-143, 2005

FCCA(Forum: Carbohydrates Coming of Age)

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