Effect of <I>Tripterygium wilfordii</I> Hook <I>f</I>, a Chinese Traditional Herb, on Macrophage Function in Mice, II. Inhibition of Inflammatory Mediator Production <I>in vivo</I>

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  • NAKAZAWA Masami
    <I>Department of Physiology, School of Medicine, Showa University</I>
  • FANG Jian-qiao
    <I>Department of Physiology, School of Medicine, Showa University</I>
  • ASANO Kazuhito
    <I>Department of Physiology, School of Medicine, Showa University</I>
  • MATSUISHI Jun
    <I>Department of Physiology, School of Medicine, Showa University</I>
  • SOMA Toshimitsu
    <I>Department of Physiology, School of Medicine, Showa University</I>
  • KOYAMA Takahiko
    <I>Department of Physiology, School of Medicine, Showa University</I>
  • KASAHARA Eri
    <I>Department of Physiology, School of Medicine, Showa University</I>
  • KASAHARA Takako
    <I>Department of Physiology, School of Medicine, Showa University</I>
  • HISAMITSU Tadashi
    <I>Department of Physiology, School of Medicine, Showa University</I>

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  • Effect of Tripterygium wilfordii Hook f, a Chinese Traditional Herb, on Macrophage Function in Mice, II. Inhibition of Inflammatory Mediator Production in vivo

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The effect of the chloroform extract ofTripterygium wilfordiiHookf (TWH) on inflammatory mediator production was examinedin vivoin BALB/c mice. Autoclaved Teflon chambers (30×10 mm) were implanted into the backs of BALB/c mice. After 10 days, 1 % zymosan A in a volume of 300 μl was injected into the chamber to induce local inflammatory responses. Exudate fluid in the chamber was withdrawn at various intervals after zymosan injection to measure the levels of inflammatory mediators, interleukin-1 β, tumor necrosis factor- α and prostaglandin E2. After zymosan injection, levels of inflammatory mediators increased rapidly, reached maximums 1 to 2 days later, then slowly decreased to baseline levels. Oral treatment with TWH extract 2 hours before zymosan injection reduced in a dose-dependent manner concentrations of both interleukin-1 i and tumor necrosis factor- α in exudate fluid obtained from mice 24 hours after injection. However, TWH extract reduced prostaglandin E2concentrations at only the highest dose used.

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