Effect of Molecular Environment and High Pressure on the Thermodynamic Stability of Nucleic Acid Structures

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  • TAKAHASHI Shuntaro
    Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University
  • SUGIMOTO Naoki
    Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University

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  • 核酸構造の熱力学的安定性に及ぼす分子環境と高圧力の効果
  • カクサン コウゾウ ノ ネツ リキガクテキ アンテイセイ ニ オヨボス ブンシ カンキョウ ト コウアツリョク ノ コウカ

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Although the pressure effect on a canonical structure of duplex is very small, G-quadruplex DNA, which is one of the non-canonical structures, destabilized with increasing pressure as well as proteins. The volumetric parameters of the formation of G-quadruplex were largely affected by molecular environments such as molecular crowding conditions. The volumetric analysis of non-canonical structures by using high pressure opens a new category in nucleic acids chemistry, which helps us to understand the information of the bulk structure and hydration, and design new drugs for nucleic acids in a living cell.<br>

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