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Mechanical evaluation of debilitated tibia diaphysis in rats during the growth period
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- Asano Takashi
- Department of Pediatric Dentistry, Kyushu Dental College
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- Tofani Iwan
- Department of Pediatric Dentistry, Kyushu Dental College
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- Gunjima Masaru
- Department of Pediatric Dentistry, Kyushu Dental College
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- Ohkura Hideichiro
- Department of Pediatric Dentistry, Kyushu Dental College
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- Maki Kenshi
- Department of Pediatric Dentistry, Kyushu Dental College
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- Kimura Mitsutaka
- Department of Pediatric Dentistry, Kyushu Dental College
Bibliographic Information
- Other Title
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- —Combination therapy with high-calcium diet and grape seed proanthocyanidin extract—
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Description
The main ingredient of grape seed proanthocyanidin extract (GSPE), is proanthocyanidin, a kind of flavonoid. Proanthocyanidins are known to have a variety of biological regulatory activities, such as antioxidant effects; however, little is known the effects on bone. In the present study, we performed mechanical analysis using three-dimensional peripheral quantitative computed tomography (pQCT), bone strength tests and quantitative analysis of a combination therapy composed of high-calcium diet and GSPE fed to rats during their growth. Forty male Wistar rats, 5 weeks old, were divided randomly into control (A), low-calcium diet (B), low-calcium/high-calcium diet (C) and low-calcium/high-calcium diet with supplementary GSPE (D) groups. After 6 weeks, the tibias were removed and cortical bone density, cross-sectional area, mineral content, cortical bone thickness, periosteal perimeters, endosteal perimeters, and stress strain index (SSI) were measured. Invasive three-point bending tests, and quantitative analysis of Ca, P, Mg and Zn using inductively coupled plasma (ICP) spectral analysis were performed. Body weights were not significantly different in the 4 groups. Cortical bone density and mineral content in group D were significantly higher than those in group C (P < 0.01) as was the periosteal perimeter (P < 0.05). SSI and three-point bending test results for group D were not significantly different than those for group C, but recovery in group D was similar to that in the control group. As for the quantitative analysis, Ca, P, and Zn levels in group D were significantly higher than those in group C (P < 0.01). Our findings suggest that a combined therapy with a high-calcium diet and GSPE can improve the quality and strength of rat tibias during their growth.
Journal
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- Pediatric Dental Journal
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Pediatric Dental Journal 15 (1), 35-42, 2005
The Japanese Society of Pediatric Dentistry
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Details 詳細情報について
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- CRID
- 1390282679359816320
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- NII Article ID
- 130004475762
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- ISSN
- 18803997
- 09172394
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- Text Lang
- en
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed
