Mapping of a gene influencing initial dental caries susceptibility to chromosome 11

DOI 1 Citations 20 References
  • Ohta Masumi
    Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine
  • Ohshima Tomoko
    Department of Oral Bacteriology, Tsurumi University School of Dental Medicine
  • Nishimura Hiroyuki
    Toin Human Science and Technology Center, Toin University of Yokohama
  • Maeda Nobuko
    Department of Oral Bacteriology, Tsurumi University School of Dental Medicine
  • Asada Yoshinobu
    Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine

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Abstract

In the present study, our purpose was to identify candidate gene(s) influencing initial dental caries susceptibility on chromosomes 7 and 11 using a Quantitative Trait Loci (QTL) analysis. On chromosome 7, five suggestive QTLs were detected in D7Mit31, D7Mit148, D7Mit262, D7Mit126 and D7Mit101. On chromosome 7, the peak LRS score was located in a region 50 cM from the centromere between marker D7Mit31 and PTH. On chromosome 11, five significant QTLs were detected in D11Mit242, D11Mit26, D11Mit339, D11Mit177 and D11Mit262. On chromosome 11, one highly significant QTL was detected in Kcnj12, the peak LRS score was located in a region 34.15 cM from the centromere marker Kcnj12. These results suggest that Kcnj12 on chromosome 11 might be one of the major gene(s) responsible for initial dental caries susceptibility.

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