Preparation of Tetrafluoroisophthalonitrile and Its Nucleophilic Substitution at 4-Position
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- TAKAOKA Akio
- Department of Chemical Technology, Tokyo Institute of Technology
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- YOKOKOHJI Osamu
- Department of Chemical Technology, Tokyo Institute of Technology
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- YAMAGUCHI Yoshiyuki
- Department of Chemical Technology, Tokyo Institute of Technology
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- ISONO Takashi
- SDS Biotech. K. K., Tokyo Research Laboratory
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- MOTOYOSHI Masatoshi
- SDS Biotech. K. K., Tokyo Research Laboratory
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- ISHIKAWA Nobuo
- Department of Chemical Technology, Tokyo Institute of Technology
Bibliographic Information
- Other Title
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- ハロゲン交換によるテトラフルオロイソフタロニトリルの合成とその求核置換反応
- ハロゲン コウカン ニ ヨル テトラフルオロ イソフタロニトリル ノ ゴウセイ
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Abstract
Tetrachloroisophthalonitrile was fluorinated into tetrafluoroisophthalonitrile with spray-dried potassium fluoride and sulfolane. Under the optimum conditions, i. e., for 5 h at 290°, the yield of tetrafluoroisophthalonitrile was ca.80%.<BR>This polyfluorinated isophthalonitrile reacted with such nucleophiles as alcohols, phenols, and amines into the corresponding 4-substituted 2, 5, 6-trifluoroisophthalonitriles in excellent yields.<BR>As a result of biocidal evaluation, it was found that these compounds possessed strong antimicrobial activities.
Journal
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- NIPPON KAGAKU KAISHI
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NIPPON KAGAKU KAISHI 1985 (11), 2155-2160, 1985-11-10
The Chemical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679366148992
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- NII Article ID
- 130004157967
- 40002844172
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- NII Book ID
- AN00186595
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- ISSN
- 21850925
- 03694577
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- NDL BIB ID
- 3056788
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed