Lanthanoid Complex of Iron-transport Protein, Transferrin --Kinetic Study on Release of the Metal from N and C Binding Sites--

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  • 鉄輸送タンパク質トランスフェリンのランタノイド錯体に関する研究-N,C両サイト錯体の解離反応速度を中心として-
  • テツ ユソウ タンパクシツ トランスフェリン ノ ランタノイド サクタイ ニ

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Abstract

Lanthanoid ions give important and useful informations to characterize the two metalbinding sites (N and C) of transferrin(Tf) which plays an important role in iron metabolism of animals. Chicken ovoTf and human seroTf bound rapidly trivalent lanthanoid ions, Ln (III), forming colorless complexes, except La(III) and Ce(III). With respect to cerium, an yellow product (λMax≈420 nm), which was assumed to be Ce(IV)-Tf complex, appeared only on a prolonged incubation of the mixture of apoTf and Ce(III) at pH 8. La(III) ion did not bind to both Tfs. The Ln(III) complexes at the two sites, N and C, differed markedly in the metal release rate from these sites in the presence of EDTA.

Journal

  • NIPPON KAGAKU KAISHI

    NIPPON KAGAKU KAISHI 1988 (4), 452-458, 1988-04-10

    The Chemical Society of Japan

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