Formation of Hydroxyl Radical from the Reactions of Copper (II) Complexes with Hydrogen Peroxide

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  • 銅(II)錯体と過酸化水素の反応によるヒドロキシルラジカルの生成

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Reactions of some copper(II) complexes with hydrogen peroxide (H2O2) to give OH radical have been studied by use of thiobarbituric acid (TBA).<BR>[Cu(en)2]2+ has, among the copper(II) comp lexes examined, the 'highest activity toward H2O2. CoPper(II) complexes with polyamine-N-polycarboxylate such as... EDTA, DTPA, EDDP and EDDA do not react with H2O2. But they yield OH radicals by the reaction with H2O2 in the presence of a reducing agent such as NADH. These results indicate that these copper(II) complexes can oxidize H2O2 because the redox potentials of copper(II) have cha nged by ligation with polyamine-N-polycarboxylate.<BR>Copper(II)-peptide or -nucleotide complexes can yield OH radical by the reaction with H2O2, but the yield of OH radical is less than that obtained from the reaction of [Cu(en)2]2+ with H2O2. This result suggests that the OH radical generated by the reaction of copper(II)complexes with H2O2 can competitively react with both deoxyribose and peptides or nucleotides. Further, in Cu(II)-nucleotide complexes, the order of the activity toward H2O2 is that of the stability of Cu(II)-nucleotide; Cu-ATP>Cu-ADP>Cu-AMP.

Journal

  • NIPPON KAGAKU KAISHI

    NIPPON KAGAKU KAISHI 1988 (4), 459-465, 1988-04-10

    The Chemical Society of Japan

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