An Overview of the History of Brain Tumor Classification and Glioma Diagnosis in WHO2016

DOI Web Site 10 References Open Access
  • Sugiyama Kazuhiko
    Department of Clinical Oncology & Neuro-oncology Program, Hiroshima University Hospital

Bibliographic Information

Other Title
  • 脳腫瘍分類の歴史とWHO2016における神経膠腫診断の重要性

Search this article

Description

The WHO classification of central nervous system tumors has been published and revised based on the entities established by well-known morphological researchers such as Harvey W. Cushing and Lucien J. Rubinstein. Recently, the molecular information about these tumors has accumulated enormously, and so the need for the classification to include, reflect, and be based on this molecular information has increased. Accordingly, WHO is establishing a new classification in May, 2016, and the main concept is an integrated diagnosis consisting of three diagnostic points: histopathology, WHO grading, and molecular information. According to the new classification, adult diffuse gliomas will be separated into two categories of astrocytoma and oligodendroglia depending on the status of IDH & ATRX gene mutation and 1p/19q co-deletion, while the entity of oligoastrocytoma is no longer adopted because of the wide diagnostic discrepancy between morphological observations and the mutually exclusive molecular characteristics of astrocytic and oligodendroglial tumor cells.

Journal

References(10)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top