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An Overview of the History of Brain Tumor Classification and Glioma Diagnosis in WHO2016
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- Sugiyama Kazuhiko
- Department of Clinical Oncology & Neuro-oncology Program, Hiroshima University Hospital
Bibliographic Information
- Other Title
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- 脳腫瘍分類の歴史とWHO2016における神経膠腫診断の重要性
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Description
The WHO classification of central nervous system tumors has been published and revised based on the entities established by well-known morphological researchers such as Harvey W. Cushing and Lucien J. Rubinstein. Recently, the molecular information about these tumors has accumulated enormously, and so the need for the classification to include, reflect, and be based on this molecular information has increased. Accordingly, WHO is establishing a new classification in May, 2016, and the main concept is an integrated diagnosis consisting of three diagnostic points: histopathology, WHO grading, and molecular information. According to the new classification, adult diffuse gliomas will be separated into two categories of astrocytoma and oligodendroglia depending on the status of IDH & ATRX gene mutation and 1p/19q co-deletion, while the entity of oligoastrocytoma is no longer adopted because of the wide diagnostic discrepancy between morphological observations and the mutually exclusive molecular characteristics of astrocytic and oligodendroglial tumor cells.
Journal
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- Japanese Journal of Neurosurgery
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Japanese Journal of Neurosurgery 25 (7), 542-547, 2016
The Japanese Congress of Neurological Surgeons
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Details 詳細情報について
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- CRID
- 1390282679382598912
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- NII Article ID
- 130005253268
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- ISSN
- 21873100
- 0917950X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed