The Validity and Value of a Quantitative SPECT Reconstruction Package (QSPECT) for evaluating Multi-center Clinical Trials(<SPECIAL ISSUE>Recent Advances in SPECT and PET in the Diagnosis of Cerebral Ischemia)

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  • Iida Hidehiro
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
  • Watabe Hiroshi
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
  • Akamatsu Tetsuya
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
  • Nakazawa Mayumi
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
  • Matsubara Keisuke
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
  • Takeuchi Asako
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
  • Iwata Michiaki
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
  • Hayashi Takuya
    Department of Investigative Radiology, National Cardiovascular Center Research Institute
  • Yokota Chiaki
    Department of Cerebrovascular Medicine, National Cardiovascular Center Hospital
  • Fukushima Kazuto
    Department of Radiology, National Cardiovascular Center Hospital
  • Fukumoto Shinji
    Department of Radiology, National Cardiovascular Center Hospital

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  • SPECTを使った脳機能画像の定量化と標準化(<特集>脳虚血とSPECT/PET)

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SPECT has the potential to provide parametric functional images, in a "quantitative" manner, for several radiotracers in vivo, as has been widely done with PET. Due to the ready availability of SPECT, in addition to the well-established delivery/transportation of various radio-ligands, SPECT has an advantage for large-scale clinical evaluation. It has, however, been considered that the accuracy and inter-institutional reproducibility of SPECT are not well verified, which is largely attributed to a lack of general consensus of reconstruction procedures (attenuation/scatter correction). We have recently developed a novel method to reconstruct SPECT images from existing projection data including appropriate corrections for scatter and attenuation in the object. We have demonstrated that this program is capable of providing accurate radio-distribution in the brain and thorax regions, and also rest-Diamox CBF using split-dose ^<123>I amphetamine (IMP). Various phantom experiments also supported the validity of inter-institutional reproducibility. These data suggested that QSPECT could be a useful tool for quantitative mapping in clinical research, allowing for large scale clinical evaluations even when using SPECT cameras from different manufacturers.

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