Historical Review and Surgical Indication of Corpus Callosotomy for Medically Intractable Epilepsies(<SPECIAL ISSUE>Epilepsy Surgery)

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  • Baba Hiroshi
    Department of Neurosurgery, National Hospital Organization Nagasaki Medical Center
  • Ono Tomonori
    Department of Neurosurgery, National Hospital Organization Nagasaki Medical Center
  • Toda Keisuke
    Department of Neurosurgery, National Hospital Organization Nagasaki Medical Center
  • Baba Shiro
    Department of Neurosurgery, National Hospital Organization Nagasaki Medical Center

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  • 脳梁離断術の歴史と手術適応(<特集>てんかん外科)
  • Historical review and surgical indication of corpus callosotomy for medically intractable epilepsies [in Japanese]

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Corpus callosotomy for medically intractable epilepsies was initially performed to prevent secondarily seizure generalization through the corpus callosum in 1940, but surgical experiences indicated that this procedure was also effective for generalized epilepsies. Corpus callosotomy has been extensively used in the past 30 years. Results to date suggest that patients with secondarily generalized epilepsy with atonic, tonic, tonic-clonic seizure appear to respond well, while patients with complex partial seizures have less favorable results except for those with frontal lobe epilepsy. However, several issues remain controversial : the criteria of patient selection, the timing of the surgery, the extent of division, and the significance of postoperative EEG changes. We reviewed the developments of corpus callosotomy and its surgical indication, and discussed the seizure control mechanisms of the corpus callosum.

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