Gene Therapy for Malignant Glioma

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  • Mizuno Masaaki
    Department of Molecular Neurosurgery, Nagoya University Graduate School of Medicine
  • Jun Yoshida
    Neurosurgery,Nagoya University Graduate School of Medicine

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  • 脳腫瘍の遺伝子治療

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Abstract

The core technology of advanced medicines provided us opportunities of gene therapy for cancer patients and there are a rapidly growing number of cancer gene therapies worldwide. For malignant brain tumors, a suicide gene therapy using herpes simplex virus thymidine kinase gene and ganciclovir was opened in USA in 1992. Recently, we made a gene therapy protocol of our own, which used cationic multilamellar liposomes entrapped with inter-feron-β(IFN-β)gene as a vector. In April 2000, we started clinical trial of IFN-βgene therapy for the patients with malignant glioma. Until now, 5 patients received the treatment and then they are under evaluation on safety and usefulness. Here we introduce history, present, and prospect of gene therapy for malignant brain tumors.

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