Primary Intraventricular Hemorrhage

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  • 原発性脳室内出血の臨床的検討

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Primary intraventricular hemorrhage (PIVH) is defined as a bleeding restricted in the ventricular system without an intraparenchymal hematoma. However, the etiology and clinical characteristics of PIVH remain unclear because of it's low incidence. Fifteen patients with PIVH were retrospectively studied concerning the clinical features, risk factors and prognosis. We investigated the clinical symptoms, medical histories, radiological findings and outcomes of these patients. Neither cerebral angiography nor magnetic resonance imaging showed abnormal findings closely related to an intraventricular hemorrhage in any patient. The volume and extent of the intraventricular hematoma were estimated by CT score (Graeb score). The most frequent symptom was consciousness disturbance (86.7%), which was clearly correlated with the Graeb score. In particular, the patients with hematoma expanding to the 3rd and /or 4th ventricle showed a poor consciousness level. The ages and past histories were not related to the consciousness level at the onset. Seven patients received external ventricular drainage with intraventricular urokinase infusion in 2 patients. One patient died of acute renal failure. Of the survivors, 9 patients exhibited good recovery (60.0%), and 4 patients recovered to moderate disability (26.7%). One patient had a poor outcome due to gastrointestinal bleeding. The amount of hematoma did not influence the outcome, however, the presence of hematoma within the 3rd and / or 4th ventricle tended to worsen the outcome. Moreover, the medical history was a more important risk factor for the outcome than the patient's age. We concluded that extensive treatment may improve the outcome even in patients with severe PIVH or elderly patients.

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