A Case of Solitary Fibrous Tumor of <i>NAB2</i> Exon 6-<i>STAT6</i> Exon 17

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  • <i>NAB2</i> exon 6-<i>STAT6</i> exon 17融合遺伝子の発現を認めた孤立性線維性腫瘍の1例

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<p>  The solitary fibrous tumor (SFT) is a relatively rare tumor among primary brain tumors. The NAB2-STAT6 fusion gene is a driver mutation of SFT and has genetic changes similar to those of hemangiopericytoma (HPC). Recently, various NAB2-STAT6 genotypes have been confirmed, and the relationship between genotypes and malignancy has been reported.</p><p>  A 49-year-old woman was referred to our department because of a 2-week history of left occipital headache and nausea. Brain magnetic resonance imaging (MRI) showed a well-demarcated and strongly enhanced mass with multi cystic compartments in the left occipital region. The mass was approximately 40 mm in diameter. A subarachnoid space was found between the tumor and the left occipital lobe, suggesting a extramedullary situated tumor. However, there was no dural tail sign. Surgical resection of the tumor was performed. The tumor was mildly elastic and hard and bleed easily. The tumor was grayish, with a clear boundary between the tumor and the brain surface. The tumor was resected sub-totally because it had invaded into the left transverse sinus. Histological examination showed moderate cellularity with round or oval nuclei, collagenous stroma, 1 mitosis per 10 high-power fields, and no necrotic areas. Immunohistochemical examination showed diffuse positivity for STAT 6 and CD 34. Genetic analysis showed NAB2 exon 6-STAT6 exon 17 fusion gene. We finally diagnosed SFT.</p>

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