Resistance Factors for Periodontal Disease

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  • 歯周疾患と抵抗因子 II  Actinomyces抗原に感作された末しょう血リンパ球の免疫学的性状
  • 第2編 <i>Actinomyces</i> 抗原に感作された末梢血リンパ球の免疫学的性状

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Rat lymphocytes sensitized with Actinomyces naeslundii ATCC 12104 strain and Actinomyces viscosus ATCC 19246 strain showed positive fluorescence from one week to four weeks after inoculation by using with fluorescence antigen techniques. These sensitized lymphocytes (effector cell) had not nature as cytotoxity against 51Cr labeled L-cells (target cell). Moreover, they had tendency to make proliferation rather than to injure to L-cells. Rat periodontal tissues transfered the lymphocytes with exracts of A. naeslundii or A. viscosus were not suffered from injury such as delayed typed hypersensitivity.<br>Development to formation of B-cell immunity and immediate typed hypersensitivity due to the effect of injected lymphocytes were not demonstrated. Macrophages migrated and phagocyted the antigenic substances in early stage in the tissue. And fibroblasts also initiated to proliferate and regenerate in the artificial injured tissue which brought about by injections.<br>From above results, we conclude that peripheral lymphocytes recognized Actinomyces antigens mainly play a role as tissue defensive factos (resistance factors) in the periodontal tissue.


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