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- 大塚 健司
- 大阪歯科大学歯周病学講座
書誌事項
- タイトル別名
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- Immunobiological activity of 41K protein (porin) derived from the cell envelope of Fusobacterium nucleatum.
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Four kinds of 41K protein fractions were prepared from a cell envelope fraction of Fusobacterium nucleatum ATCC 10953 by treatment with lithium dobecyl sulfate or sodium N-lauroyl sarcosinate. These protein fractions had porin activity, namely the ability to form hydrophilic diffusion pores in artificial liposome membrane containing them. They were also revealed to exhibit the following immunobiological activities: 1. Strong B cell mitogenicity and polyclonal B cell activation (PBA) on murine splenocytes. 2. Stimulating effects on peritoneal macrophages from a guinea pig to increase incorporation of glucosamine and release of superoxide anion and to decrease uptake of thymidine. 3. Migration enhancing activity on human blood monocytes under the conditions that the LPS had no effects. 4. Immunoadjuvant activity to increase antibody producing cells against sheep red blood cells (SRBC) in spleen of mice, after intraperitoneal injection of them with SRBC.<BR>Results of chemical analysis revealed that contamination of peptidoglycan in porin fractions was detected, while the presence of LPS were not neglected. Nevertheless, the mitogenic and PBA activities of the porin fractions on murine splenocytes were proved not to derive from LPS. These effects were detected in LPS non-responder C 3H/HeJ mice and were not depressed by ad
収録刊行物
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- 日本歯周病学会会誌
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日本歯周病学会会誌 28 (2), 445-467, 1986
特定非営利活動法人 日本歯周病学会
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詳細情報 詳細情報について
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- CRID
- 1390282679387956352
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- NII論文ID
- 110003988780
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- NII書誌ID
- AN0019129X
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- ISSN
- 1880408X
- 03850110
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- PubMed
- 3025315
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可