成人性歯周炎における初期治療効果の指標としての歯周局所ＰＧＥ２レベルについて

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  • Crevicular Fluid PGE2 Used to Evaluate the Effect of Initial Preparation in Adult Periodontitis.

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We studied parameters for measuring periodontal disease activity using gingival crevicular fluid (GCF). We evaluated prostaglandin E2 (PGE2) and cyclooxygenase 2 (COX 2) mRNA detected in GCF, and compared these with clinical parameters.<BR>GCF was taken from 40 periodontal regions of the molar teeth in 20 adult periodontal patients, 20 samples were from a probing depth (PD) exceeding 7mm and 20 from a PD of less than 3mm in each patient. Before and 1 month after initial treatment, we measured PD, clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PlI) PD exceeding 7mm was defined as seriously diseased and PD of less than 3mm PD was defined as mildly diseased. One month after initial treatment, GCF was taken agein from the same sites. PGE2 in GCF was measured using enzyme linked immunosorbent assay (ELISA), and COX 2 mRNA expression was detected by reverse transcription-polymerase chain reaction (RT-PCR).<BR>After initial treatment, PD changed from 7.2±0.5mm (mean±SD) to 3.6±1.1mm in the seriously diseased and from 2.7±0.6mm to 2.1±0.6mm in the mildly diseased. CAL changed from 8.0±1.1mm to 5.2±1.4mm in the seriously diseased and from 3.5±0.8mm to 2.9±0.9mm in the mildly diseased. In the serious diseased, PGE2 in GCF improved from 450±340pg/site to 112±70pg/site, and in the mildly diseased, from 170±200 pg/site to 70±68pg/site. PGE2 correlated with PD and CAL, but COX 2 mRNA expression showed no correlation with PGE2. These results suggest that PGE2 in GCF is effective in determining periodontal disease activity, and the effectiveness of initial preparation can be evaluated under 200pg of PGE2 per site. J Jpn Soc Periodontol, 44: 131-147, 2002.

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