Bactericidal Effect of Cetylpyridinium Chloride in Nonionic Surfactant Solution.

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  • 非イオン界面活性剤存在下における塩化セチルピリジニウムの殺菌効果

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Cetylpyridinium chloride (CPC) has been widely used in oral-care products but its antimicrobial effect decreases remarkably in the aqueous solution of a nonionic surfactant.<BR>The purpose of this study was to assess the bactericidal effect of CPC on Porphyromonas gingivalis P. gingivalis in an aqueous solution of Poly oxyethylene (60) hydrogenated castor (oils HCO-60) as a nonionic surfactant.<BR>With an increasing HCO-60 concentration, the bactericidal effect of CPC and the adsorption of CPC on P. gingivalis cells decreased remarkably.<BR>Furthermore, a CPC-based dental rinse without a nonionic surfactant showed a higher antimicrobial effect on oral bacteria than that with such a surfactant.<BR>It was concluded that a CPC-based dental rinse without a nonionic surfactant is effective.

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