Periodontal therapy by local delivery of minocycline. Clinical study of periodontal therapy by LS-007.

KURIMOTO Keiji, ISOSHIMA Osamu, NAORA Yuka, ANADA Takashi, KOBAYASHI Yoshitomo, KOBAYASHI Mitsuharu, ARAI Hideo, TAKASHIBA Shogo, NANBA Hideki, YOKOYAMA Masayuki, MITSUDA Yuka, MIZUSHIMA Yumi, NOMURA Yoshio, MURAYAMA Yoji, UEDA Masatoshi, TERANISHI Yoshihiro, FUJIWARA Kazuyuki, HASHIZUME Akiko, KAMAYA Shinpei, HOSOYAMA Yoko, UEBA Kenji, ONISHI Kazuyuki, SHIRAI Takeo, OHASHI Satoshi, HIGASHI Hirosuke, KIOKA Yoshifumi, MINAMIBAYASHI Shigeyoshi, TANAKA Mayumi, KITAMURA Takuya, MAKIGUSA Kazuto, YAMAOKA Akira, URAGUCHI Ryoji, HAGIWARA Satsuki, FUKUDA Mitsuo, ODA Sigeru, LIN Cherng-Jong, TAKEFUTA Wataru, MERA Toyotsune, MINEGISHI Daizou, UMEDA Makoto, NAKAMOTO Hiroshi, INATOMI Hirofumi, Laosrisin Narongsak, NOGUCHI Toshihide, ISHIKAWA Isao

doi:10.2329/perio.30.191

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Other Title

ミノサイクリンの局所的応用による歯周炎治療法　　ＬＳ‐００７による治療方法の臨床的検討
Clinical Study of Periodontal Therapy by LS-007
LS-007による治療方法の臨床的検討

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Abstract

Our previous studies have been performed to establish methods for local delivery of Minocycline hydrochloride (MINO: Lederle Japan, LTD, Tokyo) in a therapy for periodontal disease. This study was done clinically to evaluate the effectiveness, safety, and usefulness of a LS-007 medicine containing 2 percent titers of MINO. Forty five periodontitis patients (119 teeth) with periodontal pockets (≥4mm) participated in this study. The experimental systems were evaluated by comparing microbiological and clinical effectiveness of LS-007, placebo, and Minocycline tablet (Lederle Japan, LTD). The results were as follows, 1. The effectiveness of LS-007 was examined in two delivery system ; in one system the medicine was redelivered after one week, and in the other system after two weeks. Both systems revealed similar effectiveness until after two weeks from the last delivery. 2. When LS-007 was delivered once in a week for 4 successive weeks, LS-007 demonstrated its effectiveness until after 4 weeks from the last delivery. 3. A pretreatment with scaling prior to the application of LS-007 raised the effectiveness of LS-007. 4. The systemic delivery of Minomycine tablet demonstrated microbiologically and clinically similar effect to the local delivery of LS-007. In the systemic delivery, however, there was a subject who suffered harmful side effect of the medicine. From these results, we concluded the local delivery of LS-007 was clinically effective, safe, and useful as a therapy for periodontal disease.

Journal

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 30 (1), 191-205, 1988

JAPANESE SOCIETY OF PERIODONTOLOGY

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CRID: 1390282679388794496

NII Article ID: 110004725598

NII Book ID: AN0019129X

DOI: 10.2329/perio.30.191

ISSN: 1880408X; 03850110

PubMed: 3254385

Web Site: https://search.jamas.or.jp/link/ui/1989131026

Text Lang: ja

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